Schizophrenia: Dopamine D1 Receptor Sequence Is Normal, But Has DNA Polymorphisms
نویسندگان
چکیده
منابع مشابه
Role of silent polymorphisms within the dopamine D1 receptor associated with schizophrenia on D1-D2 receptor hetero-dimerization.
Within the coding region of the dopamine D(1) receptor (D(1)R), two synonymous polymorphisms, D(1)R(G198A) and D(1)R(G1263), have been identified and postulated to correlate with the schizophrenia phenotype. Binding studies revealed that the density of these genetic variants was much lower than the density of wild type D(1)R in the human embryonic kidney (HEK) 293 cell line, used as a model sys...
متن کاملSingle-nucleotide polymorphisms in dopamine receptor D1 are associated with heroin dependence but not impulsive behavior.
Previous studies suggested that dopamine receptors may be associated with drug dependence and impulsive behavior. In this study, we examined whether dopamine receptor D1 (DRD1) is associated with heroin dependence and the impulsive behavior in patients with heroin dependence. The participants included 367 patients with heroin dependence and 372 healthy controls from a Chinese Han population. We...
متن کاملDopamine D1 receptor gene polymorphism is associated with essential hypertension.
Dopamine has been shown to influence renal sodium excretion through a direct interaction with the dopamine receptor (DR). The dopamine D1 receptor (DRD1) has been localized to the proximal tubules and is known to increase sodium excretion by inhibiting Na-H exchanger and Na,K-ATPase activity. Defective renal dopamine production and/or DR function have been reported in essential hypertension (EH...
متن کاملStriatal dopamine D1 receptor is essential for contextual fear conditioning
Fear memory is critical for animals to trigger behavioural adaptive responses to potentially threatening stimuli, while too much or inappropriate fear may cause psychiatric problems. Numerous studies have shown that the amygdala, hippocampus and medial prefrontal cortex play important roles in Pavlovian fear conditioning. Recently, we showed that striatal neurons are required for the formation ...
متن کاملGOLFa Mediates Dopamine D1 Receptor Signaling
It is generally assumed that the coupling of dopamine D1 receptors to adenylyl cyclase is mediated by the stimulatory GTP-binding protein Gs. However, the striatum contains little Gsa subunit, whereas it expresses high levels of Golfa, a close relative of Gsa that is also expressed in olfactory receptor neurons. We used Golfa knockout mice to examine the functional coupling of D1 receptors. We ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neuropsychopharmacology
سال: 1993
ISSN: 0893-133X,1740-634X
DOI: 10.1038/npp.1993.14